[68Ga]Ga-PSMA-11 PET-CT: Local preliminary experience in prostate cancer biochemical recurrence patients
نویسندگان
چکیده
Objectives: Clinical approach of prostate cancer (PCa) biochemical recurrence (BCR) is an ever-changing topic. Prostate-specific membrane antigen positron emission tomography ([68Ga]Ga-PSMA-11 PET-CTPSMA PET-CT) has shown good potential in this field. The aim to evaluate PSMA PET-CT detection rate PCa BCR and assess its impact on clinical outcome. Material methods: Out 319 patients with who underwent between October 2015 June 2019, 70 had developed after treatment curative intent. Two groups were created: one surgery (RP group) (N: 48; 68.6%) other radiotherapy (RT 22; 31.4%). Clinical, analytical, pathological results evaluated. Results: Initial age was different (p = 0.008). RP mainly at intermediate risk (85.1% vs 42.9%, p 0.001) while RT low (8.5% 47.6%, 0.001). In groups, PETCT detected, respectively, pelvic relapse 31.3% 63.6%, extrapelvic 18.8% 31.8%. Salvage performed 61.9% (n 26) 15% 3) patients, < 0.001. Of submitted salvage treatment, 59.1% achieved complete remission. Concerning these local led remission 68.4% 13). two partial remission.Concerning rate, positive for when pre-PET PSA ≥ 0.8 ng/mL (RP) or 2.3 (RT) 0.4 3.5 (RT), > 0.05. Conclusions: Biochemical persistence therapy similar (30-40%). cut-off values detected (RT).
منابع مشابه
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ژورنال
عنوان ژورنال: Archivio italiano di urologia, andrologia
سال: 2021
ISSN: ['2282-4197', '1124-3562']
DOI: https://doi.org/10.4081/aiua.2021.1.21